Baglot, SL, Hume C, Petrie, GN, Aukema, RJ, Lightfoot SHM, Grace LM, Zhou, R, Parker, L, Rho, J, Borgland, SL, McLaughlin, RJ, Brechenmacher, L, Hill MN. (2021) Pharmacokinetics and central accumulation of f delta-9-tetrahydrocannabinol (THC) and bioactive metabolites is influenced by route of administration and sex in rats. Scientific Reports. 11: 23990. PDF


Thomas CS, Mohammadkhani A, Rana M, Baimel C, Qiao M, Borgland SL (2021) Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-related behaviours. Neuropsychopharmacology. 47(3):728-740 . BioRXiv PDF

Nettleton JE, Klancic T, Schick A, Choo AC, Chen N, Shearer J, Borgland SL, Rho J, Reimer RA. (2021) Prebiotic, probiotic, and synbiotic consumption alter behavioural variables, intestinal permeability and microbiota in BTBR mice. Microorganisms. 9(9): 1833. PDF

Lau BK, Murphy-Royal, C, Kaur, M, Bains, JS, Gordon, G, Borgland SL (2021) Obesity-induced astrocyte dysregulation of heterosynaptic plasticity within the orbitofrontal cortex. Cell Reports, 36(7): 109563. BioRXiv PDF

Borgland SL (2021) Can treatment of obesity reduce depression, or vice versa? Journal of Neuroscience and Psychiatry. (Editorial). 46 (2): E313-E318. PDF

Sallam, N, Borgland SL (2021) Insulin and endocannabinoids in the mesolimbic system. Journal of Neuroendocrinology. 33(4): e12965. PDF

Pen B, Xu O, Guo S, Borgland SL, Liu S (2021) Corticosterone attenuates reward-seeking behaviour via D2 receptor signaling in ventral tegmental area dopamine neurons. J Neuroscience. 41(7): 1566- 1581. doi: 10.1523/JNEUROSCI.2533-20.2020 PDF


Mohammadkhani, A, Borgland SL (2020) Cellular and behavioral basis of cannabinioids and opioid interactions: Implications for opioid dependence and withdrawal. Journal of Neuroscience Research.  PDF

Godfrey, N, Borgland SL (2020) Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons. J. Physiol. 598:5523-5539. BioRXiv (doi: PDF

Lau BK, Ambrose BP, Thomas CS, Qiao M, Borgland SL. (2020) Mu-opioids suppress GABAergic synaptic transmission onto orbitofrontal cortex pyramidal neurons with regional selectivity. J Neurosci 40: 5894-5907. (BioRXiv: doi: PDF

Huang S, Zhang Z, Gambeta E, Xu S-C, Thomas C , Godfrey N, Chen L, M'Dahoma S, Borgland SL, Zamponi GW (2020) Dopaminergic inputs from the ventral tegmental area into the medial prefrontal cortex modulate neuropathic pain associated behaviors in mice. Cell Reports. 31(12):107812. doi: 10.1016/j.celrep.2020.107812 PDF

Seabrook LT, Borgland SL (2020) The orbitofrontal cortex, food intake and obesity. Journal of Psychiatry and Neuroscience. 45(3): 190163. doi: 10.1503/jpn.190163 PDF

Nettleton JE, Cho NA, Klancic T, Nicolucci AC, Shearer J, Borgland SL, Johnston LA, Ramay RH, Mayengbam S, Reimer RA. (2019) Maternal low-dose aspartame and stevia consumption alters metabolism, gut microbiota, and mesolimbic reward system in rat dams and their offspring. Gut. 69: 1807-1817. PDF


Huang S, Borgland SL, Zamponi G (2019) Peripheral nerve injury-induced alterations in VTA neuron firing properties. Molecular Brain. 12:89. doi: 10.1186/s13041-019-0511-y PDF

Liu S, Borgland SL (2019) Insulin action in the mesolimbic system. Experimental Neurology. 320:113006 doi: 10.1016/j.expneurol.2019.113006. PDF

Borgland SL (2019) Releasing the brake on eating: Obesity alters neuronal and gene expression and activity that might influence overeating. Science. 364: 6447 Perspective. doi: 10.1126/science.aay0204 PDF

Borgland SL, Dayas C (2019) Hypothalamic Control of Homesostasis. Neuropharmacology. Editorial. 154:1-3. PDF

Nettleton JE, Klancic T, Schick A, Choo AC, Shearer J, Borgland SL, Chleilat F, Mayengbam S, Reimer RA. (2019) Low-dose stevia consumption perturbs gut microbiota and mesolimbic dopamine system. Nutrients. 11(6). pii: E1248. doi: 10.3390/nu11061248 PDF

Godfrey N, Borgland SL (2019) Diversity in the lateral hypothalamic input to the VTA. Neuropharmacology. 154: 4-12. PDF

Huang, S., Borgland, S.L.*, Zamponi, G.* (2019) Dopaminergic modulation of pain signals in the medial prefrontal cortex: challenges and perspectives. Neurosci Lett. 702: 71-76. *co-corresponding author PDF

Naef, L., Seabrook, L., Hsiao, J., Li., C., Borgland, S.L. (2019) Insulin in the ventral tegmental area reduces cocaine-evoked dopamine in the nucleus accumbens in vivo. Eur. J. Neurosci. 50: 2146- 2155. doi: 10.1111/ejn.14291 PDF


Lam VM, Mielnik CA, Baimel C, Beerepoot P, Espinoza S, Sukhanov I, Horsfall W, Gainetdinov RR, Borgland SL, Ramsey AJ and Salahpour A (2018) In vivo psychoactive effects of a potential novel TAAR1 antagonist. Frontiers in Pharmacology. 9: 953-958. PDF

Balsevich, G., Sticht, M., Bowles, NP, Singh, A, Lee, TTY, Li Z, Chelikani, PK, Lee, FS, Borgland, SL, Hillard, CJ, McEwen, BS, & Hill, MN (2018) A role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proc Natl Acad Sci. 115(29):7605-7610. PDF

Thomas, T.S., Baimel C., Borgland, S.L. (2018) Opioid and hypocretin neuromodulation of VTA neuronal subpopulations. British Journal of Pharmacology. 175: 1815-1833. PDF


Lau, B.K., Cota, D., Cristino, L., Borgland, S.L. (2017) Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits. Neuropharmacology. 124: 38-51. PDF

Baimel, C., Lau, B., Qiao, M., Borgland SL. (2017) Projection target defined effects of orexin and dynorphin on VTA dopamine neurons. Cell Reports. 18: 1346-1355. PDF

Burma NE, Bonin RP, Leduc-Pessah H, Baimel C, Cairncross ZF, Baimoukhametova D, Bains JS, Borgland SL, De Koninck Y, Trang T (2017) Blocking microglial pannexin-1 channels alleviates 1 morphine withdrawal. Nature Medicine. 23: 355-360. PDF

Thompson JL, Drysdale M, Baimel C, Kaur M, MacGowan T, Borgland SL. (2017) Obesity-induced deficits in structural and neuronal plasticity in the lateral orbitofrontal cortex. Neuropsychopharmacology. 42(7): 1480-1490. CIHR funded MOP102617 PDF

Mills, F., Globa, A.K., Liu, S., Cowan, C.M., Mobasser, M., Phillips, A.G., Borgland, S.L.*, Bamji, S.X*. (2017) Cadherins mediate cocaine-induced synaptic plasticity and behavioural conditioning. Nature Neuroscience. 20(4):540-549. *co-corresponding author CIHR funded PDF

Baimel, C., Borgland SL. (2017) Hypocretin/Orexin and plastic adaptations associated with drug abuse. Current Topics in Behavioural Neuroscience. 33: 283-304. NSERC funded PDF


Liu, S., Globa, A., Mills F., Naef, L., Qiao, M., Bamji, S.X., Borgland, S.L. (2016) Consumption of palatable food primes food approach behaviour by rapidly increasing synaptic density in the VTA. Proc. Natl. Acad. Sci. 113: 2520-2525. CIHR funded MOP102617 PDF

Thompson, J.L. Yang, J-H, Lau, B., Liu, S., Baimel, C., Kerr, L., Liu, F., Borgland, S.L. (2016) Age- dependent D1-D2 receptor co-activation in the lateral orbitofrontal cortex potentiates NMDA receptors and facilitates cognitive flexibility. Cerebral Cortex. 26(12): 4524-4539. PDF


Naef, L., Pitman, K., Borgland, S.L. (2015) Mesolimbic dopamine and its neuromodulators in obesity and binge eating. CNS spectrums. 20:574-583. CIHR funded MOP102617 PDF

Pitman, K., Borgland, S.L. (2015) Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet. Pharmacology & Therapeutics 154: 110-119 CIHR funded MOP102617 PDF

Baimel, C., Borgland, S.L. (2015) Orexin signaling is required for morphine-dependent plasticity in the Ventral Tegmental Area. J Neuroscience 5(18):7295-303. NSERC funded DG 372517 PDF

Pitman, K., Borgland, S.L*., McLeod, B., Puil, E. (2015) Isovaline does not activate GABA B receptor- coupled potassium currents in GABA B expressing AtT-20 cells and cultured rat hippocampal neurons. PloS One. 10(2): e0118497. *corresponding author. CIHR funded MOP102617 PDF

Liu, S., Borgland, S.L. (2015). Regulation of the VTA by feeding peptides. Neuroscience. 289C:19- 42. CIHR funded MOP102617 PDF

Baimel, C., Bartlett, S.E., Chiou, L-C., Lawrence, A-J., Muschamp , J.W., Patkar, O., Tung, L.W., Borgland, S.L*. (2015) Orexin/hypocretin role in reward: implications for opioid and other addictions. Br. J. Pharmacol. 172(2):334-48. NSERC funded 272517 PDF


Pitman, K., Puil, E., Borgland, S.L. (2014) GABAB receptor activation decreases terminal dopamine release in the Nucleus Accumbens. Eur. J. Neurosci. 40: 3472-80. CIHR funded MOP102617 PDF

Ferris, MJ, Milenkovic, M, Liu, S., Mielnik CA, John, CE, Espana RA, Sotnikova TD, Gainetdinov RR, Borgland, SL., Jones SR, Ramsey AJ (2014) Sustained NMDA receptor hypofunction remodels the dopamine system and impairs phasic signaling. Eur. J. Neuroscience. 40(1):2255-63. CIHR funded MOP102617 PDF

Muschamp, J.W., Hollander, J.A., Thompson, J.L, Hassinger, L.C, Chen, M., Gallo, M.S., Kamenecka, T.M., Borgland, S.L, Kenny, P.J., Carlezon, Jr, W.A. (2014) Opposing actions of hypocretin (orexin) and dynorphin co-packaged in hypothalamic inputs to midbrain dopamine systems. Proc. Natl. Acad. Sci. 111(16):E1648-55. NSERC funded DG 372517 PDF

Brigidi, G.S., Sun, Y, Beccano-Kelly, D., Pitman, K., Borgland, S.L., Milnerwood, A., Bamji, S.X.(2014) Palmitoylation of δ catenin by DHHC5 is Essential for Activity-dependent Enhancements of Synapse Structure and Efficacy. Nat. Neurosci. 17(4): 522-532. CIHR funded MOP102617 PDF


Liu, S., Labouèbe, G., Karunakaran, S., Clee, M., Borgland, S.L*. (2013) Effect of insulin on excitatory synaptic transmission onto dopamine neurons of the Ventral Tegmental Area in a mouse model of hyperinsulinemia. Nutrition and Diabetes. 3:e97. doi: 10.1038/nutd.2013.38. CIHR funded MOP102617

Karatsoreos, I., Thaler, J., Borgland, S.L., Champagne, F., Hurd, Y., and Hill, M. (2013) Food for Thought: Hormonal, Experiential and Neural Influences on Feeding and Obesity. J. Neurosci. 33(45):17610 –17616 CIHR funded MOP102617

Labouèbe, G., Liu, S., Dias, C., Zou, H.Y., Wong, C.Y.J., Karunakaran, S., Clee, M., Phillips, A.G., Boutrel, B., Borgland, S.L*. (2013) Insulin mediates long term depression of VTA dopamine neurons via an endocannabinoid mediated mechanism. Nature Neuroscience. 16: 300-308. CIHR funded MOP102617

Thompson, J. T., Borgland, S.L.* (2013) Presynaptic leptin action suppresses excitatory synaptic transmission onto ventral tegmental area dopamine neurons. Biol. Psych. 73(9):860-868. CIHR funded MOP102617


Patayl, R., Woo, E.Y., Borgland, S.L*. (2012) Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell. Front. Behav. Neurosci. doi: 10.3389/fnbeh.2012.00082 NSERC funded 272517

Baimel, C., Borgland, S.L.* (2012) Hypocretin modulation of drug-induced synaptic plasticity. Prog Brain Res. 198: 123-131. NSERC funded 272517

Baimel, C., Borgland, S.L.*, Corrigall, W. (2012) Cocaine and nicotine research illustrates a range of hypocretin mechanisms in addiction. Vitam Horm. 89: 291-313. NSERC funded 272517

Mebel, D. M., Wong J. C.Y., Dong., J. Y., Borgland, S.L.* (2012). Insulin in the Ventral Tegmental Area modulates somatodendritic dopamine release and hedonic feeding. Eur. J. Neurosci. 36(3):2336-46. FEATURE ARTICLE CIHR funded MOP102617


McGinty, V.B., Hayden, B.Y., Heilbronner, S.R., Dumont, E.C., Graves, S.M., Mirrion, M.M., du Hoffman, J., Sartor, G.C., Espana, R.A., Millan, E.Z., DiFeliceantonio, A.G., Marchant, N.J., Napier, T.C., Root, D.H., Borgland, S.L., Treadway, M.T., Floresco, S.B., McGinty, J.F., Haber, S. (2011) Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational and Neural Networks conference. Behav. Brain Res. 225: 348-57. CIHR funded MOP102617

Thompson, J.L., Borgland, S.L.* (2011) A role for hypocretin/orexin in motivation. Behav. Brain Res. 217:446-453. NSERC funded PDF

Borgland, S.L*., Labouebe, G. (2010) Orexin/Hypocretin in psychiatric disorders: present state of knowledge and future potential. Neuropsychopharmacology. 35: 353-354. (Hot Topics Review) CIHR funded MOP102617 PDF

Borgland, S.L. Ungless, M.A. Bonci A. (2010) Convergent actions of orexin/hypocretin and CRF on dopamine neurons: emerging players in addiction. Brain Res. 1314: 139-144. NSERC funded 272517 PDF

Borgland, S.L*., Chang, S-J, Bowers, M.S., Thompson, J.L., Vittoz, N.M., Floresco, S., Chou, J., Chen, B., Bonci, A. (2009). Orexin A/Hypocretin1 promotes motivation selectively for highly salient positive reinforcers. J. Neurosci. 29: 11215-11225. NSERC funded 272517

Bonci, A., Borgland, S. (2009) Role of Orexin/Hypocretin and CRF in the formation of drug- dependent synaptic plasticity in the mesolimbic system. Neuropharmacology. 56: Suppl 1:107-11.NSERC funded 272517

Borgland, S.L*., Storm, E., Bonci, A. (2008) Orexin B mediates enhanced synaptic transmission to the VTA. European Journal of Neuroscience. 28: 1546-1555.

Richards, J., Simms, J., Steesland, P., Taha, S.A, Borgland, S.L., Bonci, A., Bartlett, S. E. (2008) Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in long-evans rats. Psychopharmacology. 199: 109-117.

Sarti, F.*, Borgland, S.L.*, Kharazia, V., Bonci, A. (2007) Acute cocaine exposure alters spine density and long term potentiation in the ventral tegmental area. Eur. J. Neurosci. 26: 749: 756.*Contributed equally.

deLecea, L., Jones, B.E., Boutrel, B., Borgland, S.L., Nishino, S., Busber, M., di Leone, R. (2006) Addiction and Arousal: Alternative roles for hypothalamic peptides. J. Neurosci. 26: 10372-5.

Borgland, S.L., Taha, S., Sarti, F., Fields, H.L., Bonci, A. (2006) Orexin A signaling in dopamine neurons is critical for cocaine induced synaptic plasticity and behavioral sensitization. Neuron. 49, 589-601.

Suvarna, N., Borgland, S.L., Wang, J., Phamluong, K., Auberson, Y.P., Bonci, A., Ron, D. (2005) Ethanol alters trafficking and functional NMDA receptor NR2 subunit ratio. J. Biol. Chem. 280: 31450-9.

Borgland, S.L., Malenka R., Bonci, A. (2004) Acute and chronic cocaine-induced potentiation of synaptic strength in the VTA: electrophysiological and behavioral correlates in individual rats. J. Neurosci. 24: 7482-7490.

Borgland, S.L., Connor, M., Osborne, P.B., Furness J.B., Christie, M.J. (2003) Opioid agonists have different efficacy profiles for G-protein activation, rapid desensitization and endocytosis of mu-opioid receptors. J. Biol. Chem. 278: 18776-84.

Borgland, S.L., Ryan, R.M., Ball, H., Connor, M., Christie, M.J. (2002) Prostaglandin E 2 inhibits calcium current in two sub populations of acutely isolated mouse trigeminal sensory neurons. J. Physiol. 539.2: 433-444.

Bowen, G.P., Borgland, S.L., Lam, M., Libermann, T.A., Wong, N.C.W., and Muruve, D.A. (2002) Adenovirus Vector-Induced Inflammation: Capsid Dependent Expression of RANTES Requires NFB. Hum. Gene Ther. 13: 367-379.

Borgland, S.L., Connor, M., Christie, M.J. (2001) Nociceptin inhibits calcium currents in a subpopulation of nociceptive trigeminal sensory neurons. J. Physiol. 536.1: 35-47.

Borgland, S.L. (2001) Acute opioid receptor desensitization and tolerance: is there a link? Clin. Exp. Pharmacol. Physiol. 28: 147-154. (Review)

Borgland, S.L., Bowen, G.P., Wong, N.C.W., Libermann, T.A. and Muruve., D.A., (2000) Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NFkB. J. Virol. 74: 3941-3947.

Connor, M, Borgland, S.L. and Christie, M.J. (1999) Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats. Br. J. Pharmacol. 128: 1561-1569.

Borgland, S.L. and Parkinson, F.E. (1998) Effect of adenosine receptor agonists on release of the nucleoside analogue [ 3 H]formycin B from cultured smooth muscle DDT 1 -MF2 cells. Eur. J. Pharmacol. 346: 339-344.

Borgland, S.L., Castanon, M., Spevak, W., and Parkinson, F.E. (1998) Effects of propentofylline on adenosine receptor activity in Chinese hamster ovary cell lines transfected with human A1, A2A, or A2 B receptors and a luciferase reporter gene. Can. J. Pharmacol. Physiol. 76: 1132-1138.

Borgland, S.L. and Parkinson, F.E. (1997) Uptake and release of [ 3 H]formycin B via sodium- dependent nucleoside transport in mouse leukemic L1210/MA27.1 cells. J. Pharmacol. Exp. Ther. 281: 347-353.